There exists a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to decrease afferent soreness transmission and create analgesia. Consequently, medication like clonidine that concentrate on alpha-two receptors can influence the transmission of ache. Clonidine is dispersed in breast milk; https://cassh925gyt2.qodsblog.com/profile