Substitution at R3 that has a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency Along with the halide analogs (74g–h) displaying best the potency from the group. Even more optimization led to the invention of 74i–j, with 74k as quite possibly the most Energetic compound https://collintofqf.thenerdsblog.com/37126378/indazole-protecting-group-fundamentals-explained