A sporicidal system, normally shipped by gassing, may be used to help microbiological control. Some substantial scale isolators give an opening, generally called a mouse gap, to permit continual removal of sealed product. The WHO tips stipulate that manufacturers need to establish and adhere to thorough routine maintenance schedules https://medium.com/@tailinscitech/applications-and-benefits-of-tailin-containment-isolator-for-handling-high-potency-materials-8c66a55dbcf7